:root {
  --paper: #F3F5F6;
  --paper-raised: #FFFFFF;
  --ink: #0E1B24;
  --muted: #55707D;
  --line: #D7DEE2;
  --accent: #0E6E6E;
  --accent-ink: #FFFFFF;
  --tag-bg: #E7ECEE;
  --tier-preclinical: #8A6D3B;
  --tier-earlyclin: #0E6E6E;
  --tier-approved: #2F5233;
  --tier-mixed: #7A4A4A;

  /* dark bookend sections (hero / footer / deep-dive headers) */
  --navy-deep: #081620;
  --navy-mid: #10293A;
  --navy-raised: #14314480;
  --navy-line: #1F3C4C;
  --on-navy: #EAF2F4;
  --on-navy-muted: #8FAAB7;
  --teal-bright: #35C2C2;

  /* compound accent colours, used only on Deep Dive headers */
  --cpd-bpc157: #2F5233;
  --cpd-tesamorelin: #0E6E6E;
  --cpd-retatrutide: #1B5A8C;
  --cpd-kisspeptin: #6B3F8C;

  --grid-line: rgba(14,27,36,0.06);
}

@media (prefers-color-scheme: dark) {
  :root:not([data-theme="light"]) {
    --paper: #0E1419;
    --paper-raised: #161D23;
    --ink: #E7ECEF;
    --muted: #93A1AA;
    --line: #26303A;
    --accent: #35C2C2;
    --accent-ink: #0B1316;
    --tag-bg: #1C262D;
    --tier-preclinical: #D3AE6F;
    --tier-earlyclin: #35C2C2;
    --tier-approved: #6FBE78;
    --tier-mixed: #C98888;
    --grid-line: rgba(234,242,244,0.07);
  }
}
:root[data-theme="dark"] {
  --paper: #0E1419;
  --paper-raised: #161D23;
  --ink: #E7ECEF;
  --muted: #93A1AA;
  --line: #26303A;
  --accent: #35C2C2;
  --accent-ink: #0B1316;
  --tag-bg: #1C262D;
  --tier-preclinical: #D3AE6F;
  --tier-earlyclin: #35C2C2;
  --tier-approved: #6FBE78;
  --tier-mixed: #C98888;
  --grid-line: rgba(234,242,244,0.07);
}

* { box-sizing: border-box; }

html { color-scheme: light dark; }

body {
  background: var(--paper);
  color: var(--ink);
  font-family: "Source Sans 3", system-ui, -apple-system, sans-serif;
  padding: 0;
  margin: 0;
  line-height: 1.65;
}

a { color: var(--accent); }

.ps-wrap { max-width: 880px; margin: 0 auto; padding: 0 24px; }

/* ---------- top nav ---------- */
.ps-nav {
  position: sticky;
  top: 0;
  z-index: 10;
  background: var(--paper);
  border-bottom: 1px solid var(--line);
  backdrop-filter: blur(6px);
}

.ps-nav-inner {
  max-width: 880px;
  margin: 0 auto;
  padding: 14px 24px;
  display: flex;
  align-items: center;
  justify-content: space-between;
  gap: 16px;
}

.ps-nav .ps-wordmark {
  font-family: "Source Serif 4", Georgia, serif;
  font-weight: 700;
  font-size: 1.15rem;
  color: var(--ink);
  text-decoration: none;
  white-space: nowrap;
}

.ps-nav-links {
  display: flex;
  gap: 18px;
  flex-wrap: wrap;
  font-family: "IBM Plex Mono", monospace;
  font-size: 0.72rem;
  letter-spacing: 0.02em;
}

.ps-nav-links a {
  color: var(--muted);
  text-decoration: none;
}
.ps-nav-links a:hover { color: var(--accent); }

@media (max-width: 720px) {
  .ps-nav-links { display: none; }
}

/* ---------- hero ---------- */
.ps-hero {
  padding-block: 64px 48px;
  border-bottom: 1px solid var(--line);
}

.ps-hero .ps-eyebrow {
  font-family: "IBM Plex Mono", monospace;
  font-size: 0.72rem;
  letter-spacing: 0.12em;
  text-transform: uppercase;
  color: var(--accent);
  margin-bottom: 14px;
}

.ps-hero h1 {
  font-family: "Source Serif 4", Georgia, serif;
  font-weight: 700;
  font-size: clamp(2.3rem, 6vw, 3.4rem);
  line-height: 1.1;
  margin: 0 0 18px;
  text-wrap: balance;
  max-width: 14ch;
}

.ps-hero .ps-sub {
  font-size: 1.1rem;
  color: var(--muted);
  max-width: 56ch;
  margin: 0 0 20px;
}

.ps-disclosure-pill {
  display: inline-flex;
  align-items: center;
  gap: 8px;
  font-family: "IBM Plex Mono", monospace;
  font-size: 0.74rem;
  color: var(--muted);
  background: var(--tag-bg);
  border: 1px solid var(--line);
  border-radius: 20px;
  padding: 6px 14px;
}

.ps-disclosure-pill b { color: var(--ink); }

/* ---------- generic section scaffolding ---------- */
.ps-section {
  padding-block: 52px;
  border-bottom: 1px solid var(--line);
}

.ps-section-head {
  display: flex;
  flex-direction: column;
  gap: 8px;
  margin-bottom: 28px;
  max-width: 68ch;
}

.ps-kicker {
  font-family: "IBM Plex Mono", monospace;
  font-size: 0.7rem;
  letter-spacing: 0.1em;
  text-transform: uppercase;
  color: var(--accent);
}

.ps-section-head h2 {
  font-family: "Source Serif 4", Georgia, serif;
  font-weight: 700;
  font-size: clamp(1.5rem, 4vw, 1.9rem);
  margin: 0;
  text-wrap: balance;
}

.ps-section-head p {
  margin: 0;
  color: var(--muted);
  font-size: 0.98rem;
}

/* ---------- purpose ---------- */
.ps-purpose-grid {
  display: grid;
  grid-template-columns: 1fr;
  gap: 22px;
}
@media (min-width: 680px) {
  .ps-purpose-grid { grid-template-columns: 1.3fr 1fr; }
}
.ps-purpose-grid p { margin: 0 0 14px; max-width: 58ch; }
.ps-purpose-grid p:last-child { margin-bottom: 0; }

.ps-disclosure-box {
  background: var(--paper-raised);
  border: 1px solid var(--line);
  border-left: 3px solid var(--accent);
  border-radius: 6px;
  padding: 18px 20px;
}
.ps-disclosure-box .ps-label {
  font-family: "IBM Plex Mono", monospace;
  font-size: 0.68rem;
  letter-spacing: 0.08em;
  text-transform: uppercase;
  color: var(--accent);
  margin-bottom: 8px;
  display: block;
}
.ps-disclosure-box p { font-size: 0.9rem; color: var(--ink); }

/* ---------- card grids ---------- */
.ps-card-grid {
  display: grid;
  grid-template-columns: 1fr;
  gap: 16px;
}
@media (min-width: 680px) {
  .ps-card-grid.cols-2 { grid-template-columns: 1fr 1fr; }
  .ps-card-grid.cols-3 { grid-template-columns: repeat(3, 1fr); }
}

.ps-card {
  background: var(--paper-raised);
  border: 1px solid var(--line);
  border-radius: 8px;
  padding: 18px;
  display: flex;
  flex-direction: column;
  gap: 8px;
}

.ps-card h3 {
  font-family: "Source Serif 4", Georgia, serif;
  font-weight: 600;
  font-size: 1.05rem;
  margin: 0;
}

.ps-card p { margin: 0; font-size: 0.9rem; color: var(--muted); }

.ps-soon-card {
  border-style: dashed;
  display: flex;
  flex-direction: column;
  gap: 6px;
}
.ps-soon-tag {
  font-family: "IBM Plex Mono", monospace;
  font-size: 0.64rem;
  letter-spacing: 0.06em;
  text-transform: uppercase;
  color: var(--muted);
  width: fit-content;
  background: var(--tag-bg);
  border-radius: 3px;
  padding: 2px 7px;
}

/* ---------- evidence tier legend ---------- */
.ps-tier-legend {
  display: flex;
  flex-wrap: wrap;
  gap: 10px;
  margin-top: 20px;
}
.ps-tier {
  display: flex;
  align-items: center;
  gap: 7px;
  font-family: "IBM Plex Mono", monospace;
  font-size: 0.76rem;
  background: var(--paper-raised);
  border: 1px solid var(--line);
  border-radius: 20px;
  padding: 6px 12px 6px 8px;
}
.ps-tier-dot { width: 9px; height: 9px; border-radius: 50%; flex-shrink: 0; }
.ps-tier-dot.preclinical { background: var(--tier-preclinical); }
.ps-tier-dot.earlyclin { background: var(--tier-earlyclin); }
.ps-tier-dot.approved { background: var(--tier-approved); }
.ps-tier-dot.mixed { background: var(--tier-mixed); }

/* ---------- compound deep dive ---------- */
.ps-deep-dive {
  background: var(--paper-raised);
  border: 1px solid var(--line);
  border-radius: 10px;
  padding: 26px 28px;
}

.ps-deep-dive-head {
  display: flex;
  align-items: baseline;
  justify-content: space-between;
  gap: 12px;
  flex-wrap: wrap;
  margin-bottom: 6px;
}

.ps-deep-dive h3 {
  font-family: "Source Serif 4", Georgia, serif;
  font-weight: 700;
  font-size: 1.5rem;
  margin: 0;
}

.ps-evidence-split {
  display: grid;
  grid-template-columns: 1fr;
  gap: 16px;
  margin-top: 18px;
}
@media (min-width: 680px) {
  .ps-evidence-split { grid-template-columns: 1fr 1fr; }
}

.ps-evidence-col {
  border: 1px solid var(--line);
  border-radius: 8px;
  padding: 14px 16px;
}
.ps-evidence-col.weak { border-left: 3px solid var(--tier-mixed); }
.ps-evidence-col.established { border-left: 3px solid var(--tier-preclinical); }

.ps-evidence-col h4 {
  font-family: "IBM Plex Mono", monospace;
  font-size: 0.72rem;
  letter-spacing: 0.04em;
  text-transform: uppercase;
  color: var(--muted);
  margin: 0 0 8px;
}
.ps-evidence-col p { margin: 0; font-size: 0.92rem; }

/* ---------- regulation / science prose blocks ---------- */
.ps-prose { max-width: 68ch; }
.ps-prose p { margin: 0 0 14px; }
.ps-prose p:last-child { margin-bottom: 0; }

/* ---------- founder feature ---------- */
.ps-founder {
  display: flex;
  flex-direction: column;
  gap: 16px;
  background: var(--paper-raised);
  border: 1px solid var(--line);
  border-radius: 10px;
  padding: 24px;
}
@media (min-width: 680px) {
  .ps-founder { flex-direction: row; align-items: center; }
}
.ps-founder-logo {
  background: #FFFFFF;
  border: 1px solid var(--line);
  border-radius: 8px;
  padding: 16px;
  display: flex;
  align-items: center;
  justify-content: center;
  flex-shrink: 0;
}
.ps-founder-logo img { width: 160px; height: auto; display: block; }
.ps-founder-text p { margin: 0 0 10px; font-size: 0.95rem; }
.ps-founder-text p:last-child { margin-bottom: 0; }
.ps-founder-text a { font-family: "IBM Plex Mono", monospace; font-size: 0.8rem; }

/* ---------- newsletter ---------- */
.ps-newsletter {
  background: var(--ink);
  color: var(--paper);
  border-radius: 10px;
  padding: 30px 28px;
  display: flex;
  flex-direction: column;
  gap: 14px;
}
.ps-newsletter h2 {
  font-family: "Source Serif 4", Georgia, serif;
  margin: 0;
  font-size: 1.4rem;
}
.ps-newsletter p { margin: 0; color: #B9C2C7; max-width: 52ch; font-size: 0.92rem; }
.ps-newsletter-form {
  display: flex;
  gap: 10px;
  flex-wrap: wrap;
  margin-top: 6px;
}
.ps-newsletter-form input {
  flex: 1;
  min-width: 200px;
  padding: 11px 14px;
  border-radius: 6px;
  border: 1px solid #39454D;
  background: #1B262D;
  color: var(--paper);
  font-family: "Source Sans 3", sans-serif;
  font-size: 0.92rem;
}
.ps-newsletter-form button {
  font-family: "IBM Plex Mono", monospace;
  font-size: 0.8rem;
  font-weight: 500;
  background: var(--accent);
  color: var(--accent-ink);
  border: none;
  border-radius: 6px;
  padding: 11px 18px;
  cursor: pointer;
}
.ps-newsletter-note { font-family: "IBM Plex Mono", monospace; font-size: 0.7rem; color: #7E8C93; }

/* ---------- footer ---------- */
.ps-footer {
  padding-block: 36px 60px;
  font-size: 0.85rem;
  color: var(--muted);
}
.ps-footer .ps-footer-links {
  display: flex;
  gap: 16px;
  flex-wrap: wrap;
  font-family: "IBM Plex Mono", monospace;
  font-size: 0.74rem;
  margin-bottom: 16px;
}
.ps-footer .ps-footer-links a { color: var(--muted); }
.ps-footer p { max-width: 64ch; margin: 0 0 8px; }
.ps-footer p:last-child { margin-bottom: 0; }

/* ---------- evidence ladder ---------- */
.ps-ladder {
  position: relative;
  display: flex;
  flex-direction: column;
  padding-left: 40px;
  margin-top: 8px;
}
.ps-ladder::before {
  content: '';
  position: absolute;
  left: 13px;
  top: 8px;
  bottom: 8px;
  width: 2px;
  background: linear-gradient(to bottom, var(--line), var(--accent));
  opacity: 0.6;
}
.ps-ladder-step {
  position: relative;
  padding-bottom: 32px;
}
.ps-ladder-step:last-child { padding-bottom: 0; }
.ps-ladder-step::before {
  content: '';
  position: absolute;
  left: -40px;
  top: 3px;
  width: 26px;
  height: 26px;
  border-radius: 50%;
  background: var(--paper-raised);
  border: 2px solid var(--line);
  box-shadow: 0 0 0 4px var(--paper);
}
.ps-ladder-step:nth-child(2)::before { border-color: var(--tier-preclinical); }
.ps-ladder-step:nth-child(3)::before { border-color: var(--tier-earlyclin); }
.ps-ladder-step:nth-child(4)::before { border-color: var(--accent); }
.ps-ladder-step.capstone::before { background: var(--accent); border-color: var(--accent); }
.ps-ladder-step .ps-level {
  font-family: "IBM Plex Mono", monospace;
  font-size: 0.68rem;
  letter-spacing: 0.08em;
  text-transform: uppercase;
  color: var(--accent);
  margin-bottom: 4px;
}
.ps-ladder-step h3 {
  font-family: "Source Serif 4", Georgia, serif;
  font-weight: 600;
  font-size: 1.1rem;
  margin: 0 0 6px;
}
.ps-ladder-step p {
  margin: 0;
  font-size: 0.92rem;
  color: var(--muted);
  max-width: 56ch;
}

/* ---------- checklist ---------- */
.ps-checklist {
  display: grid;
  grid-template-columns: 1fr;
  gap: 10px;
}
@media (min-width: 680px) {
  .ps-checklist.cols-2 { grid-template-columns: 1fr 1fr; }
}
.ps-checklist-item {
  display: flex;
  gap: 10px;
  align-items: flex-start;
  background: var(--paper-raised);
  border: 1px solid var(--line);
  border-radius: 7px;
  padding: 12px 14px;
}
.ps-checklist-item .ps-flag-mark {
  font-family: "IBM Plex Mono", monospace;
  font-size: 0.78rem;
  color: var(--accent);
  flex-shrink: 0;
  line-height: 1.5;
}
.ps-checklist-item p { margin: 0; font-size: 0.9rem; }
.ps-checklist-item strong { display: block; font-size: 0.92rem; margin-bottom: 2px; }

/* ---------- sub-page hero (shorter than homepage hero) ---------- */
.ps-subhero {
  padding-block: 44px 36px;
  border-bottom: 1px solid var(--line);
}
.ps-subhero .ps-eyebrow { font-family: "IBM Plex Mono", monospace; font-size: 0.72rem; letter-spacing: 0.12em; text-transform: uppercase; color: var(--accent); margin-bottom: 12px; }
.ps-subhero h1 { font-family: "Source Serif 4", Georgia, serif; font-weight: 700; font-size: clamp(2rem, 5.5vw, 2.9rem); line-height: 1.12; margin: 0 0 14px; text-wrap: balance; max-width: 18ch; }
.ps-subhero .ps-sub { font-size: 1.05rem; color: var(--muted); max-width: 58ch; margin: 0 0 18px; }

.ps-breadcrumb {
  font-family: "IBM Plex Mono", monospace;
  font-size: 0.74rem;
  color: var(--muted);
  margin-bottom: 18px;
}
.ps-breadcrumb a { color: var(--muted); }
.ps-breadcrumb a:hover { color: var(--accent); }

/* ---------- placeholder link row ---------- */
.ps-placeholder-row {
  display: flex;
  flex-wrap: wrap;
  gap: 10px;
}
.ps-placeholder-link {
  display: inline-flex;
  align-items: center;
  gap: 6px;
  font-family: "IBM Plex Mono", monospace;
  font-size: 0.78rem;
  color: var(--ink);
  background: var(--paper-raised);
  border: 1px solid var(--line);
  border-radius: 20px;
  padding: 8px 14px;
  text-decoration: none;
}
.ps-placeholder-link:hover { border-color: var(--accent); color: var(--accent); }

/* ---------- evidence library: browse/filter ---------- */
.el-controls {
  display: flex;
  flex-direction: column;
  gap: 14px;
  margin-bottom: 28px;
}
.el-search {
  width: 100%;
  padding: 12px 16px;
  border-radius: 8px;
  border: 1px solid var(--line);
  background: var(--paper-raised);
  color: var(--ink);
  font-family: "Source Sans 3", sans-serif;
  font-size: 0.95rem;
  transition: border-color 0.15s ease, box-shadow 0.15s ease;
}
.el-search:focus-visible {
  outline: none;
  border-color: var(--accent);
  box-shadow: 0 0 0 3px rgba(14,110,110,0.18);
}
.el-filter-row {
  display: flex;
  flex-wrap: wrap;
  gap: 8px;
}
.el-filter-chip {
  font-family: "IBM Plex Mono", monospace;
  font-size: 0.74rem;
  background: var(--paper-raised);
  border: 1px solid var(--line);
  border-radius: 20px;
  padding: 6px 13px;
  cursor: pointer;
  color: var(--muted);
  transition: border-color 0.15s ease, color 0.15s ease, background 0.15s ease;
}
.el-filter-chip:hover { border-color: var(--accent); color: var(--accent); }
.el-filter-chip.active {
  background: var(--accent);
  color: var(--accent-ink);
  border-color: var(--accent);
}
.el-filter-chip:focus-visible { outline: 2px solid var(--accent); outline-offset: 2px; }
.el-count {
  font-family: "IBM Plex Mono", monospace;
  font-size: 0.78rem;
  color: var(--muted);
  margin-bottom: 14px;
}

.el-grid {
  display: grid;
  grid-template-columns: 1fr;
  gap: 14px;
}
@media (min-width: 680px) {
  .el-grid { grid-template-columns: 1fr 1fr; }
}

.el-profile-card {
  display: block;
  background: var(--paper-raised);
  border: 1px solid var(--line);
  border-top: 3px solid var(--line);
  border-radius: 8px;
  padding: 20px;
  text-decoration: none;
  color: var(--ink);
}
.el-profile-card:hover { border-color: var(--accent); border-top-color: var(--accent); }
.el-profile-card h3 {
  font-family: "Source Serif 4", Georgia, serif;
  font-size: 1.2rem;
  margin: 0 0 4px;
}
.el-profile-card .el-alt-name {
  font-family: "IBM Plex Mono", monospace;
  font-size: 0.74rem;
  color: var(--muted);
  margin-bottom: 10px;
}
.el-profile-card .el-summary {
  font-size: 0.9rem;
  color: var(--muted);
  margin-bottom: 14px;
}
.el-profile-card .el-meta-row {
  display: flex;
  flex-wrap: wrap;
  gap: 6px;
}
.el-coming-card {
  border-style: dashed;
  display: flex;
  flex-direction: column;
  gap: 6px;
  justify-content: center;
}

/* ---------- evidence stage badge (qualitative, not a score) ---------- */
.el-stage-badge {
  display: inline-flex;
  align-items: center;
  gap: 7px;
  font-family: "IBM Plex Mono", monospace;
  font-size: 0.74rem;
  font-weight: 500;
  border-radius: 20px;
  padding: 6px 13px;
  border: 1px solid transparent;
}
.el-stage-badge .dot { width: 8px; height: 8px; border-radius: 50%; flex-shrink: 0; }
.el-stage-badge.preclinical { background: #F2EADA; color: #6B5324; }
.el-stage-badge.early-human { background: #DCF2F0; color: #0E5E5E; }
.el-stage-badge.developing { background: #DDEBE0; color: #244F2F; }
.el-stage-badge.mixed { background: #F2E0DD; color: #6B2F28; }
.el-stage-badge.established { background: #D7ECD9; color: #1E4D28; }

:root:not([data-theme="light"]) .el-stage-badge.preclinical { background: #332812; color: #D3AE6F; }
:root:not([data-theme="light"]) .el-stage-badge.early-human { background: #0F2928; color: #35C2C2; }
:root:not([data-theme="light"]) .el-stage-badge.developing { background: #16261A; color: #6FBE78; }
:root:not([data-theme="light"]) .el-stage-badge.mixed { background: #2B1917; color: #D98F85; }
:root:not([data-theme="light"]) .el-stage-badge.established { background: #132A18; color: #7FDB8C; }
@media (prefers-color-scheme: dark) {
  :root[data-theme="dark"] .el-stage-badge.preclinical { background: #332812; color: #D3AE6F; }
  :root[data-theme="dark"] .el-stage-badge.early-human { background: #0F2928; color: #35C2C2; }
  :root[data-theme="dark"] .el-stage-badge.developing { background: #16261A; color: #6FBE78; }
  :root[data-theme="dark"] .el-stage-badge.mixed { background: #2B1917; color: #D98F85; }
  :root[data-theme="dark"] .el-stage-badge.established { background: #132A18; color: #7FDB8C; }
}

.el-not-score {
  font-size: 0.86rem;
  color: var(--muted);
  max-width: 62ch;
  margin-top: 10px;
}

/* ---------- profile page ---------- */
.el-profile-head {
  display: flex;
  flex-direction: column;
  gap: 12px;
}
.el-profile-head h1 {
  font-family: "Source Serif 4", Georgia, serif;
  font-weight: 700;
  font-size: clamp(2rem, 6vw, 2.8rem);
  margin: 0;
}
.el-alt-names {
  font-family: "IBM Plex Mono", monospace;
  font-size: 0.82rem;
  color: var(--muted);
}

.el-overview-grid {
  display: grid;
  grid-template-columns: 1fr;
  gap: 18px;
  margin-top: 10px;
}
@media (min-width: 680px) {
  .el-overview-grid { grid-template-columns: repeat(3, 1fr); }
}
.el-overview-item .el-ov-label {
  font-family: "IBM Plex Mono", monospace;
  font-size: 0.66rem;
  letter-spacing: 0.06em;
  text-transform: uppercase;
  color: var(--accent);
  margin-bottom: 4px;
}
.el-overview-item p { margin: 0; font-size: 0.92rem; }

/* ---------- mechanism ---------- */
.el-mech-row {
  display: grid;
  grid-template-columns: 1fr;
  gap: 14px;
}
@media (min-width: 680px) {
  .el-mech-row { grid-template-columns: 1fr 1fr; }
}
.el-mech-col {
  border: 1px solid var(--line);
  border-radius: 8px;
  padding: 16px;
}
.el-mech-col.established { border-left: 3px solid var(--tier-approved); }
.el-mech-col.proposed { border-left: 3px solid var(--tier-preclinical); }
.el-mech-col h4 {
  font-family: "IBM Plex Mono", monospace;
  font-size: 0.7rem;
  text-transform: uppercase;
  letter-spacing: 0.04em;
  color: var(--muted);
  margin: 0 0 8px;
}
.el-mech-col p { margin: 0; font-size: 0.92rem; }

/* ---------- 5-tier evidence breakdown ---------- */
.el-evidence-rows {
  display: flex;
  flex-direction: column;
  gap: 2px;
}
.el-evidence-row {
  display: grid;
  grid-template-columns: 1fr auto;
  align-items: start;
  gap: 14px;
  padding: 16px;
  background: var(--paper-raised);
  border: 1px solid var(--line);
}
.el-evidence-row:first-child { border-radius: 8px 8px 0 0; }
.el-evidence-row:last-child { border-radius: 0 0 8px 8px; }
.el-evidence-row + .el-evidence-row { border-top: none; }
.el-evidence-row h4 { font-family: "Source Serif 4", Georgia, serif; font-size: 1rem; font-weight: 600; margin: 0 0 4px; }
.el-evidence-row p { margin: 0; font-size: 0.88rem; color: var(--muted); max-width: 54ch; }

.el-avail-tag {
  font-family: "IBM Plex Mono", monospace;
  font-size: 0.68rem;
  text-transform: uppercase;
  letter-spacing: 0.04em;
  border-radius: 4px;
  padding: 4px 9px;
  white-space: nowrap;
}
.el-avail-tag.available { background: #D7ECD9; color: #1E4D28; }
.el-avail-tag.limited { background: #F2EADA; color: #6B5324; }
.el-avail-tag.mixed { background: #F2E0DD; color: #6B2F28; }
.el-avail-tag.none { background: var(--tag-bg); color: var(--muted); }
:root:not([data-theme="light"]) .el-avail-tag.available { background: #132A18; color: #7FDB8C; }
:root:not([data-theme="light"]) .el-avail-tag.limited { background: #332812; color: #D3AE6F; }
:root:not([data-theme="light"]) .el-avail-tag.mixed { background: #2B1917; color: #D98F85; }
@media (prefers-color-scheme: dark) {
  :root[data-theme="dark"] .el-avail-tag.available { background: #132A18; color: #7FDB8C; }
  :root[data-theme="dark"] .el-avail-tag.limited { background: #332812; color: #D3AE6F; }
  :root[data-theme="dark"] .el-avail-tag.mixed { background: #2B1917; color: #D98F85; }
}

/* ---------- key research citation cards ---------- */
.el-citation {
  background: var(--paper-raised);
  border: 1px solid var(--line);
  border-radius: 8px;
  padding: 18px 20px;
  margin-bottom: 14px;
}
.el-citation:last-child { margin-bottom: 0; }
.el-citation .el-cite-title {
  font-family: "Source Serif 4", Georgia, serif;
  font-weight: 600;
  font-size: 1.02rem;
  margin: 0 0 6px;
}
.el-citation .el-cite-meta {
  font-family: "IBM Plex Mono", monospace;
  font-size: 0.74rem;
  color: var(--muted);
  margin-bottom: 10px;
}
.el-citation dl {
  display: grid;
  grid-template-columns: auto 1fr;
  gap: 4px 12px;
  margin: 0 0 10px;
  font-size: 0.88rem;
}
.el-citation dt { color: var(--muted); }
.el-citation dd { margin: 0; }
.el-citation .el-cite-link {
  font-family: "IBM Plex Mono", monospace;
  font-size: 0.78rem;
}
.el-verify-flag {
  display: inline-block;
  font-family: "IBM Plex Mono", monospace;
  font-size: 0.72rem;
  color: #6B2F28;
  background: #F2E0DD;
  border-radius: 4px;
  padding: 2px 8px;
}
:root:not([data-theme="light"]) .el-verify-flag { background: #2B1917; color: #D98F85; }
@media (prefers-color-scheme: dark) {
  :root[data-theme="dark"] .el-verify-flag { background: #2B1917; color: #D98F85; }
}

/* ---------- callout boxes: does-not-establish / conflicts ---------- */
.el-callout {
  border: 1px solid var(--line);
  border-left: 3px solid var(--accent);
  border-radius: 8px;
  padding: 18px 20px;
  background: var(--paper-raised);
}
.el-callout ul { margin: 10px 0 0; padding-left: 20px; }
.el-callout li { margin-bottom: 8px; font-size: 0.92rem; }
.el-callout li:last-child { margin-bottom: 0; }

.el-callout.conflict { border-left-color: var(--tier-mixed, #7A4A4A); }

/* ---------- common claim pipeline ---------- */
.el-claim-pipeline {
  display: flex;
  flex-direction: column;
  gap: 0;
  border: 1px solid var(--line);
  border-radius: 8px;
  overflow: hidden;
}
.el-claim-step {
  padding: 16px 20px;
  border-bottom: 1px solid var(--line);
}
.el-claim-step:last-child { border-bottom: none; }
.el-claim-step .el-claim-label {
  font-family: "IBM Plex Mono", monospace;
  font-size: 0.68rem;
  letter-spacing: 0.06em;
  text-transform: uppercase;
  color: var(--accent);
  margin-bottom: 6px;
}
.el-claim-step.claim { background: var(--tag-bg); }
.el-claim-step p { margin: 0; font-size: 0.94rem; }

/* ---------- clinical trials tracker ---------- */
.ct-banner {
  background: var(--navy-deep);
  color: var(--on-navy);
  border-radius: 10px;
  border-left: 3px solid var(--teal-bright);
  padding: 20px 24px;
  margin-bottom: 28px;
}
.ct-banner p { margin: 0; font-family: "Source Serif 4", Georgia, serif; font-style: italic; font-size: 1.15rem; }
.ct-banner .ct-sub { font-family: "Source Sans 3", sans-serif; font-style: normal; font-size: 0.86rem; color: var(--on-navy-muted); margin-top: 8px; }

.ct-status-badge {
  display: inline-flex;
  align-items: center;
  gap: 6px;
  font-family: "IBM Plex Mono", monospace;
  font-size: 0.68rem;
  text-transform: uppercase;
  letter-spacing: 0.04em;
  border-radius: 4px;
  padding: 4px 9px;
  white-space: nowrap;
}
.ct-status-badge .dot { width: 7px; height: 7px; border-radius: 50%; flex-shrink: 0; }
.ct-status-badge.recruiting { background: #DCF2F0; color: #0E5E5E; }
.ct-status-badge.active { background: #DDEBE0; color: #244F2F; }
.ct-status-badge.completed { background: #D7ECD9; color: #1E4D28; }
.ct-status-badge.unknown { background: var(--tag-bg); color: var(--muted); }
.ct-status-badge.terminated { background: #F2E0DD; color: #6B2F28; }
:root:not([data-theme="light"]) .ct-status-badge.recruiting { background: #0F2928; color: #35C2C2; }
:root:not([data-theme="light"]) .ct-status-badge.active { background: #16261A; color: #6FBE78; }
:root:not([data-theme="light"]) .ct-status-badge.completed { background: #132A18; color: #7FDB8C; }
:root:not([data-theme="light"]) .ct-status-badge.terminated { background: #2B1917; color: #D98F85; }
@media (prefers-color-scheme: dark) {
  :root[data-theme="dark"] .ct-status-badge.recruiting { background: #0F2928; color: #35C2C2; }
  :root[data-theme="dark"] .ct-status-badge.active { background: #16261A; color: #6FBE78; }
  :root[data-theme="dark"] .ct-status-badge.completed { background: #132A18; color: #7FDB8C; }
  :root[data-theme="dark"] .ct-status-badge.terminated { background: #2B1917; color: #D98F85; }
}

.ct-results-tag {
  font-family: "IBM Plex Mono", monospace;
  font-size: 0.66rem;
  text-transform: uppercase;
  color: var(--muted);
  border: 1px solid var(--line);
  border-radius: 4px;
  padding: 3px 8px;
}
.ct-results-tag.yes { border-color: var(--tier-approved); color: var(--tier-approved); }

.ct-sort-row {
  display: flex;
  align-items: center;
  gap: 10px;
  margin-bottom: 14px;
  font-family: "IBM Plex Mono", monospace;
  font-size: 0.78rem;
  color: var(--muted);
}
.ct-sort-row select {
  font-family: "IBM Plex Mono", monospace;
  font-size: 0.78rem;
  background: var(--paper-raised);
  border: 1px solid var(--line);
  border-radius: 6px;
  padding: 6px 10px;
  color: var(--ink);
}
.ct-sort-row select:focus-visible, .el-search:focus-visible { outline: 2px solid var(--accent); outline-offset: 2px; }

.ct-grid { display: flex; flex-direction: column; gap: 14px; }

.ct-trial-card {
  display: block;
  background: var(--paper-raised);
  border: 1px solid var(--line);
  border-left: 3px solid var(--line);
  border-radius: 8px;
  padding: 18px 20px;
  text-decoration: none;
  color: var(--ink);
}
.ct-trial-card.clickable:hover { border-color: var(--accent); border-left-color: var(--accent); }
.ct-trial-card .ct-card-top {
  display: flex;
  justify-content: space-between;
  align-items: flex-start;
  gap: 12px;
  flex-wrap: wrap;
  margin-bottom: 8px;
}
.ct-trial-card .ct-compound {
  font-family: "IBM Plex Mono", monospace;
  font-size: 0.7rem;
  text-transform: uppercase;
  letter-spacing: 0.05em;
  color: var(--accent);
  margin-bottom: 4px;
}
.ct-trial-card h3 { font-family: "Source Serif 4", Georgia, serif; font-size: 1.08rem; margin: 0 0 10px; font-weight: 600; }
.ct-trial-card .ct-badges { display: flex; gap: 6px; flex-wrap: wrap; }
.ct-trial-card .ct-meta-grid {
  display: grid;
  grid-template-columns: repeat(2, 1fr);
  gap: 6px 18px;
  font-size: 0.84rem;
  color: var(--muted);
  margin-top: 12px;
}
@media (min-width: 680px) {
  .ct-trial-card .ct-meta-grid { grid-template-columns: repeat(4, 1fr); }
}
.ct-trial-card .ct-meta-grid dt { font-family: "IBM Plex Mono", monospace; font-size: 0.64rem; text-transform: uppercase; color: var(--muted); }
.ct-trial-card .ct-meta-grid dd { margin: 0; color: var(--ink); font-size: 0.86rem; }
.ct-trial-card .ct-registry-link { font-family: "IBM Plex Mono", monospace; font-size: 0.76rem; margin-top: 12px; display: inline-block; }
.ct-no-detail { font-family: "IBM Plex Mono", monospace; font-size: 0.68rem; color: var(--muted); }

/* registry vs published distinction */
.ct-rvp-split {
  display: grid;
  grid-template-columns: 1fr;
  gap: 16px;
}
@media (min-width: 680px) {
  .ct-rvp-split { grid-template-columns: 1fr 1fr; }
}
.ct-rvp-col {
  border: 1px solid var(--line);
  border-radius: 8px;
  padding: 16px 18px;
}
.ct-rvp-col.registry { border-top: 3px solid var(--muted); }
.ct-rvp-col.published { border-top: 3px solid var(--accent); }
.ct-rvp-col h4 { font-family: "IBM Plex Mono", monospace; font-size: 0.72rem; text-transform: uppercase; letter-spacing: 0.04em; margin: 0 0 10px; }
.ct-rvp-col.registry h4 { color: var(--muted); }
.ct-rvp-col.published h4 { color: var(--accent); }
.ct-rvp-col p { margin: 0 0 8px; font-size: 0.9rem; }
.ct-rvp-col p:last-child { margin-bottom: 0; }

.ct-detail-row { display: flex; flex-direction: column; gap: 4px; margin-bottom: 14px; }
.ct-detail-row:last-child { margin-bottom: 0; }
.ct-detail-row .ct-dt { font-family: "IBM Plex Mono", monospace; font-size: 0.68rem; text-transform: uppercase; letter-spacing: 0.04em; color: var(--accent); }
.ct-detail-row .ct-dd { font-size: 0.95rem; }

/* ---------- on-this-page nav ---------- */
.ps-toc {
  position: sticky;
  top: 58px;
  background: var(--paper-raised);
  border: 1px solid var(--line);
  border-radius: 8px;
  padding: 14px 16px;
  margin-bottom: 28px;
  z-index: 5;
}
.ps-toc summary {
  font-family: "IBM Plex Mono", monospace;
  font-size: 0.74rem;
  text-transform: uppercase;
  letter-spacing: 0.06em;
  color: var(--accent);
  cursor: pointer;
}
.ps-toc-list {
  display: flex;
  flex-wrap: wrap;
  gap: 6px 14px;
  margin-top: 10px;
  font-size: 0.84rem;
}
.ps-toc-list a { color: var(--ink); text-decoration: none; }
.ps-toc-list a:hover { color: var(--accent); }

/* ---------- 3-column comparison ---------- */
.ps-tricol {
  display: grid;
  grid-template-columns: 1fr;
  gap: 14px;
}
@media (min-width: 780px) {
  .ps-tricol { grid-template-columns: repeat(3, 1fr); }
}
.ps-tricol-item {
  border: 1px solid var(--line);
  border-radius: 8px;
  padding: 16px 18px;
  border-top: 3px solid var(--accent);
}
.ps-tricol-item h3 { font-family: "Source Serif 4", Georgia, serif; font-size: 1.05rem; margin: 0 0 8px; }
.ps-tricol-item .ps-tricol-q { font-size: 0.86rem; font-style: italic; color: var(--muted); margin-bottom: 8px; }
.ps-tricol-item p { margin: 0; font-size: 0.9rem; }

/* ---------- illustrative mock-up ---------- */
.ps-mockup-wrap { position: relative; margin: 10px 0 24px; }
.ps-mockup-flag {
  display: inline-block;
  font-family: "IBM Plex Mono", monospace;
  font-size: 0.7rem;
  font-weight: 600;
  letter-spacing: 0.05em;
  text-transform: uppercase;
  background: #B5542A;
  color: #FFFFFF;
  border-radius: 4px;
  padding: 5px 11px;
  margin-bottom: 10px;
}
.ps-mockup {
  background: var(--paper-raised);
  border: 2px dashed #B5542A;
  border-radius: 8px;
  padding: 20px 22px;
  position: relative;
  overflow: hidden;
}
.ps-mockup::before {
  content: 'ILLUSTRATIVE EXAMPLE';
  position: absolute;
  top: 40%;
  left: 50%;
  transform: translate(-50%, -50%) rotate(-20deg);
  font-family: "IBM Plex Mono", monospace;
  font-size: 2.2rem;
  font-weight: 700;
  color: var(--ink);
  opacity: 0.07;
  white-space: nowrap;
  pointer-events: none;
}
.ps-mockup-title { font-family: "IBM Plex Mono", monospace; font-size: 0.78rem; font-weight: 600; margin-bottom: 12px; border-bottom: 1px solid var(--line); padding-bottom: 10px; }
.ps-mockup dl { display: grid; grid-template-columns: auto 1fr; gap: 6px 14px; font-size: 0.86rem; margin: 0; position: relative; }
.ps-mockup dt { color: var(--muted); }
.ps-mockup dd { margin: 0; font-family: "IBM Plex Mono", monospace; }

/* ---------- chromatogram SVG wrapper ---------- */
.ps-chrom-wrap { background: var(--paper-raised); border: 1px solid var(--line); border-radius: 8px; padding: 16px; margin: 14px 0; }
.ps-chrom-wrap svg { width: 100%; height: auto; display: block; }
.ps-chrom-caption { font-family: "IBM Plex Mono", monospace; font-size: 0.72rem; color: var(--muted); margin-top: 8px; }

/* ---------- may/may-not split (reusing rvp pattern with new names) ---------- */
.ps-split-may {
  display: grid;
  grid-template-columns: 1fr;
  gap: 16px;
}
@media (min-width: 680px) {
  .ps-split-may { grid-template-columns: 1fr 1fr; }
}
.ps-split-col { border: 1px solid var(--line); border-radius: 8px; padding: 16px 18px; }
.ps-split-col.may { border-top: 3px solid var(--tier-approved); }
.ps-split-col.maynot { border-top: 3px solid var(--tier-mixed); }
.ps-split-col h4 { font-family: "IBM Plex Mono", monospace; font-size: 0.72rem; text-transform: uppercase; letter-spacing: 0.04em; margin: 0 0 10px; }
.ps-split-col.may h4 { color: var(--tier-approved); }
.ps-split-col.maynot h4 { color: var(--tier-mixed); }
.ps-split-col ul { margin: 0; padding-left: 18px; }
.ps-split-col li { font-size: 0.9rem; margin-bottom: 8px; }
.ps-split-col li:last-child { margin-bottom: 0; }

/* ---------- read-a-coa flow checklist ---------- */
.ps-flow {
  display: flex;
  flex-wrap: wrap;
  gap: 8px;
  align-items: center;
}
.ps-flow-step {
  background: var(--paper-raised);
  border: 1px solid var(--line);
  border-radius: 20px;
  padding: 7px 14px;
  font-family: "IBM Plex Mono", monospace;
  font-size: 0.78rem;
}
.ps-flow-arrow { color: var(--muted); font-size: 0.9rem; }

/* ---------- definition inline ---------- */
.ps-term { border-bottom: 1px dotted var(--accent); cursor: help; }

/* ---------- regulatory page: last-reviewed banner ---------- */
.reg-reviewed {
  display: flex;
  align-items: center;
  gap: 8px;
  flex-wrap: wrap;
  font-family: "IBM Plex Mono", monospace;
  font-size: 0.76rem;
  background: var(--tag-bg);
  border: 1px solid var(--line);
  border-radius: 20px;
  padding: 7px 14px;
  width: fit-content;
  color: var(--muted);
}
.reg-reviewed b { color: var(--ink); }

.reg-disclaimer {
  background: var(--paper-raised);
  border: 1px solid var(--line);
  border-left: 3px solid var(--brass, #8A6D3B);
  border-radius: 8px;
  padding: 16px 18px;
  font-size: 0.88rem;
  color: var(--muted);
}
.reg-disclaimer strong { color: var(--ink); }

/* ---------- definition box ---------- */
.reg-definition {
  background: var(--paper-raised);
  border: 1px solid var(--line);
  border-radius: 8px;
  padding: 16px 18px;
  margin: 14px 0;
}
.reg-definition .reg-term {
  font-family: "Source Serif 4", Georgia, serif;
  font-weight: 600;
  font-size: 1rem;
  color: var(--accent);
  margin-bottom: 6px;
}
.reg-definition p { margin: 0; font-size: 0.92rem; }
.reg-definition .reg-source {
  display: block;
  margin-top: 8px;
  font-family: "IBM Plex Mono", monospace;
  font-size: 0.7rem;
  color: var(--muted);
}

/* ---------- jurisdiction cards ---------- */
.reg-jur-grid {
  display: grid;
  grid-template-columns: 1fr;
  gap: 14px;
}
@media (min-width: 780px) {
  .reg-jur-grid { grid-template-columns: repeat(3, 1fr); }
}
.reg-jur-card {
  border: 1px solid var(--line);
  border-radius: 8px;
  padding: 16px 18px;
  border-top: 3px solid var(--muted);
}
.reg-jur-card.has-status { border-top-color: var(--tier-approved); }
.reg-jur-card h4 {
  font-family: "IBM Plex Mono", monospace;
  font-size: 0.72rem;
  text-transform: uppercase;
  letter-spacing: 0.04em;
  margin: 0 0 8px;
  color: var(--muted);
}
.reg-jur-card .reg-jur-status {
  font-family: "Source Serif 4", Georgia, serif;
  font-weight: 600;
  font-size: 1rem;
  margin-bottom: 6px;
}
.reg-jur-card p { margin: 0; font-size: 0.88rem; color: var(--muted); }

/* ---------- compound regulatory summary card ---------- */
.reg-compound-card {
  background: var(--paper-raised);
  border: 1px solid var(--line);
  border-radius: 10px;
  padding: 20px 22px;
  margin-bottom: 16px;
}
.reg-compound-card:last-child { margin-bottom: 0; }
.reg-compound-card h3 { font-family: "Source Serif 4", Georgia, serif; font-size: 1.15rem; margin: 0 0 12px; }

/* ---------- source callout ---------- */
.reg-source-callout {
  font-family: "IBM Plex Mono", monospace;
  font-size: 0.76rem;
  color: var(--accent);
  display: block;
  margin-top: 6px;
}

/* ==========================================================================
   SITE-WIDE NAVIGATION, BREADCRUMBS, FOOTER, RELATED-CONTENT
   Shared across every Primary Source page (not The Synthesis).
   ========================================================================== */

/* ---------- nav menu container ---------- */
.ps-nav-menu {
  display: flex;
  align-items: center;
  gap: 4px;
  flex-wrap: wrap;
}

.ps-nav-link {
  font-family: "IBM Plex Mono", monospace;
  font-size: 0.78rem;
  color: var(--muted);
  text-decoration: none;
  padding: 8px 10px;
  border-radius: 6px;
}
.ps-nav-link:hover { color: var(--ink); }
.ps-nav-link.ps-nav-active { color: var(--accent); font-weight: 500; }

/* ---------- dropdown ---------- */
.ps-nav-dropdown { position: relative; }

.ps-nav-dd-trigger {
  display: inline-flex;
  align-items: center;
  gap: 5px;
  font-family: "IBM Plex Mono", monospace;
  font-size: 0.78rem;
  color: var(--muted);
  background: none;
  border: none;
  padding: 8px 10px;
  border-radius: 6px;
  cursor: pointer;
}
.ps-nav-dd-trigger:hover { color: var(--ink); }
.ps-nav-dropdown.ps-nav-active .ps-nav-dd-trigger { color: var(--accent); font-weight: 500; }
.ps-nav-dropdown.is-open .ps-nav-dd-trigger { color: var(--ink); background: var(--tag-bg); }

.ps-nav-caret {
  width: 6px;
  height: 6px;
  border-right: 1.5px solid currentColor;
  border-bottom: 1.5px solid currentColor;
  transform: rotate(45deg);
  margin-top: -3px;
  transition: transform 0.15s ease;
}
.ps-nav-dropdown.is-open .ps-nav-caret { transform: rotate(-135deg); margin-top: 2px; }

.ps-nav-dd-panel {
  display: none;
  position: absolute;
  top: calc(100% + 8px);
  left: 0;
  min-width: 260px;
  background: var(--paper-raised);
  border: 1px solid var(--line);
  border-radius: 10px;
  padding: 8px;
  box-shadow: 0 12px 28px rgba(0,0,0,0.12);
  z-index: 50;
}
.ps-nav-dropdown.is-open .ps-nav-dd-panel { display: block; }

.ps-nav-dd-item {
  display: flex;
  flex-direction: column;
  gap: 2px;
  padding: 9px 10px;
  border-radius: 7px;
  text-decoration: none;
  color: var(--ink);
}
.ps-nav-dd-item:hover { background: var(--tag-bg); }
.ps-nav-dd-item.is-current { background: var(--tag-bg); }
.ps-nav-dd-title { font-family: "Source Serif 4", Georgia, serif; font-weight: 600; font-size: 0.92rem; }
.ps-nav-dd-title.is-current { color: var(--accent); }
.ps-nav-dd-desc { font-size: 0.78rem; color: var(--muted); }

/* ---------- mobile toggle ---------- */
.ps-nav-toggle {
  display: none;
  flex-direction: column;
  justify-content: center;
  gap: 4px;
  width: 34px;
  height: 34px;
  background: none;
  border: 1px solid var(--line);
  border-radius: 7px;
  cursor: pointer;
  padding: 0;
  flex-shrink: 0;
}
.ps-nav-toggle span {
  display: block;
  width: 16px;
  height: 1.5px;
  background: var(--ink);
  margin: 0 auto;
}

@media (max-width: 880px) {
  .ps-nav-toggle { display: flex; }

  .ps-nav-menu {
    display: none;
    position: absolute;
    top: 100%;
    left: 0;
    right: 0;
    flex-direction: column;
    align-items: stretch;
    gap: 0;
    background: var(--paper);
    border-bottom: 1px solid var(--line);
    padding: 8px 20px 16px;
    max-height: calc(100vh - 56px);
    overflow-y: auto;
  }
  .ps-nav-menu.is-open { display: flex; }

  .ps-nav-link { padding: 12px 4px; border-bottom: 1px solid var(--line); border-radius: 0; }

  .ps-nav-dropdown { width: 100%; }
  .ps-nav-dd-trigger {
    width: 100%;
    justify-content: space-between;
    padding: 12px 4px;
    border-bottom: 1px solid var(--line);
    border-radius: 0;
  }
  .ps-nav-dd-panel {
    display: none;
    position: static;
    box-shadow: none;
    border: none;
    border-radius: 0;
    padding: 0 0 6px 10px;
    background: transparent;
  }
  .ps-nav-dropdown.is-open .ps-nav-dd-panel { display: block; }
}

/* ---------- footer grid ---------- */
.ps-footer-grid {
  display: grid;
  grid-template-columns: 1fr;
  gap: 24px;
  padding-bottom: 28px;
  border-bottom: 1px solid var(--line);
  margin-bottom: 20px;
}
@media (min-width: 680px) {
  .ps-footer-grid { grid-template-columns: repeat(3, 1fr); }
}
.ps-footer-col { display: flex; flex-direction: column; gap: 8px; }
.ps-footer-col-title {
  font-family: "IBM Plex Mono", monospace;
  font-size: 0.68rem;
  text-transform: uppercase;
  letter-spacing: 0.06em;
  color: var(--accent);
  margin-bottom: 4px;
}
.ps-footer-col a { color: var(--muted); text-decoration: none; font-size: 0.88rem; }
.ps-footer-col a:hover { color: var(--ink); }
.ps-footer-bottom p { margin: 0 0 8px; max-width: 64ch; font-size: 0.85rem; color: var(--muted); }
.ps-footer-bottom p:last-child { margin-bottom: 0; }

/* ---------- continue exploring ---------- */
.ps-continue {
  padding-block: 40px;
  border-top: 1px solid var(--line);
}
.ps-continue-head {
  font-family: "IBM Plex Mono", monospace;
  font-size: 0.72rem;
  text-transform: uppercase;
  letter-spacing: 0.06em;
  color: var(--muted);
  margin-bottom: 14px;
}
.ps-continue-grid {
  display: grid;
  grid-template-columns: 1fr;
  gap: 12px;
}
@media (min-width: 680px) {
  .ps-continue-grid { grid-template-columns: repeat(3, 1fr); }
}
.ps-continue-item {
  display: block;
  background: var(--paper-raised);
  border: 1px solid var(--line);
  border-radius: 8px;
  padding: 14px 16px;
  text-decoration: none;
  color: var(--ink);
}
.ps-continue-item:hover { border-color: var(--accent); }
.ps-continue-item .ps-continue-label {
  font-family: "IBM Plex Mono", monospace;
  font-size: 0.66rem;
  text-transform: uppercase;
  color: var(--accent);
  margin-bottom: 4px;
}
.ps-continue-item .ps-continue-title { font-family: "Source Serif 4", Georgia, serif; font-weight: 600; font-size: 0.95rem; }

/* ==========================================================================
   VISUAL IDENTITY PASS — article-hero system, motifs, icons, motion
   ========================================================================== */

/* ---------- sticky nav + subtle polish ---------- */
.ps-nav {
  position: sticky;
  top: 0;
  z-index: 60;
  box-shadow: 0 1px 0 var(--line);
}

/* ---------- generic dark/navy section (hero + footer bookends) ---------- */
.ph-navy {
  background: var(--navy-deep);
  color: var(--on-navy);
  position: relative;
  overflow: hidden;
}
.ph-navy a { color: var(--teal-bright); }
.ph-navy .ps-breadcrumb { color: var(--on-navy-muted); }
.ph-navy .ps-breadcrumb a { color: var(--on-navy-muted); }
.ph-navy .ps-breadcrumb a:hover { color: var(--teal-bright); }

/* faint scientific grid texture, used behind dark sections */
.ph-grid-texture {
  position: absolute;
  inset: 0;
  background-image:
    linear-gradient(var(--navy-line) 1px, transparent 1px),
    linear-gradient(90deg, var(--navy-line) 1px, transparent 1px);
  background-size: 42px 42px;
  opacity: 0.35;
  pointer-events: none;
}

/* ---------- article hero (Deep Dives, Evidence profiles, trials, learn, regulation) ---------- */
.ph-hero {
  position: relative;
  padding-block: 52px 40px;
}
.ph-hero .ps-wrap { position: relative; z-index: 2; }

.ph-hero .ps-eyebrow {
  font-family: "IBM Plex Mono", monospace;
  font-size: 0.72rem;
  letter-spacing: 0.12em;
  text-transform: uppercase;
  color: var(--teal-bright);
  margin-bottom: 14px;
  display: flex;
  align-items: center;
  gap: 8px;
}

.ph-hero h1 {
  font-family: "Source Serif 4", Georgia, serif;
  font-weight: 700;
  font-size: clamp(2rem, 5.5vw, 2.9rem);
  line-height: 1.1;
  margin: 0 0 14px;
  text-wrap: balance;
  max-width: 20ch;
  color: var(--on-navy);
}

.ph-hero .ps-sub {
  font-size: 1.05rem;
  color: var(--on-navy-muted);
  max-width: 58ch;
  margin: 0 0 20px;
}

.ph-hero .ph-motif {
  position: absolute;
  top: 0;
  right: 0;
  bottom: 0;
  width: 42%;
  opacity: 0.5;
  z-index: 1;
  pointer-events: none;
}
.ph-hero .ph-motif svg { width: 100%; height: 100%; }

@media (max-width: 780px) {
  .ph-hero .ph-motif { width: 60%; opacity: 0.28; }
}

/* profile-style hero head (evidence profiles, trial detail pages) inside dark hero */
.ph-hero .el-profile-head h1 {
  font-family: "Source Serif 4", Georgia, serif;
  font-weight: 700;
  font-size: clamp(2rem, 5.5vw, 2.8rem);
  color: var(--on-navy);
  margin: 0;
  max-width: 22ch;
}
.ph-hero .el-alt-names { color: var(--on-navy-muted); }
.ph-hero .el-stage-badge.preclinical,
.ph-hero .ct-status-badge.unknown { background: #332812; color: #D3AE6F; }
.ph-hero .el-stage-badge.early-human,
.ph-hero .ct-status-badge.recruiting { background: #0F2928; color: #35C2C2; }
.ph-hero .el-stage-badge.developing,
.ph-hero .ct-status-badge.active { background: #16261A; color: #6FBE78; }
.ph-hero .el-stage-badge.mixed { background: #2B1917; color: #D98F85; }
.ph-hero .el-stage-badge.established,
.ph-hero .ct-status-badge.completed { background: #132A18; color: #7FDB8C; }
.ph-hero .ct-status-badge.terminated { background: #2B1917; color: #D98F85; }

/* reg-reviewed / disclosure pill variants for dark hero */
.ph-hero .reg-reviewed {
  background: rgba(234,242,244,0.08);
  border-color: var(--navy-line);
  color: var(--on-navy-muted);
}
.ph-hero .reg-reviewed b { color: var(--on-navy); }
.ph-hero .ps-disclosure-pill {
  background: rgba(234,242,244,0.08);
  border: 1px solid var(--navy-line);
  color: var(--on-navy-muted);
}
.ph-hero .ps-disclosure-pill b { color: var(--on-navy); }

/* compound-specific accent on Deep Dive heroes — SVG motifs use stroke/fill="currentColor" */
.ph-hero.cpd-bpc157 { --cpd-color: #6FBE78; }
.ph-hero.cpd-tesamorelin { --cpd-color: var(--teal-bright); }
.ph-hero.cpd-retatrutide { --cpd-color: #6FB4F0; }
.ph-hero.cpd-kisspeptin { --cpd-color: #C79BE8; }
.ph-hero[class*="cpd-"] .ps-eyebrow { color: var(--cpd-color); }
.ph-hero[class*="cpd-"] .ph-motif { color: var(--cpd-color); }

/* category label chip within hero (Deep Dive / Evidence Library / Clinical Trial / Learn / Regulation) */
.ph-cat-chip {
  display: inline-flex;
  align-items: center;
  gap: 6px;
  font-family: "IBM Plex Mono", monospace;
  font-size: 0.68rem;
  letter-spacing: 0.06em;
  text-transform: uppercase;
  background: rgba(234,242,244,0.1);
  border: 1px solid var(--navy-line);
  border-radius: 20px;
  padding: 5px 12px;
  margin-bottom: 14px;
  color: var(--on-navy-muted);
}
.ph-cat-chip .ph-icon { width: 13px; height: 13px; }

/* ---------- icon set ---------- */
.ph-icon {
  width: 16px;
  height: 16px;
  flex-shrink: 0;
  stroke: currentColor;
  fill: none;
  stroke-width: 1.6;
  stroke-linecap: round;
  stroke-linejoin: round;
  vertical-align: -3px;
}

/* ---------- homepage: masthead hero ---------- */
.ph-site-hero {
  position: relative;
  padding-block: 64px 56px;
  overflow: hidden;
}
.ph-site-hero-grid {
  position: relative;
  z-index: 2;
  display: grid;
  grid-template-columns: 1fr;
  gap: 36px;
  align-items: center;
}
@media (min-width: 880px) {
  .ph-site-hero-grid { grid-template-columns: 1.1fr 0.9fr; }
}
.ph-masthead-label {
  font-family: "IBM Plex Mono", monospace;
  font-size: 0.72rem;
  letter-spacing: 0.16em;
  text-transform: uppercase;
  color: var(--teal-bright);
  margin-bottom: 18px;
}
.ph-site-hero h1 {
  font-family: "Source Serif 4", Georgia, serif;
  font-weight: 700;
  font-size: clamp(2.4rem, 6vw, 3.6rem);
  line-height: 1.08;
  letter-spacing: -0.01em;
  margin: 0 0 16px;
  color: var(--on-navy);
  text-wrap: balance;
}
.ph-site-hero .ph-tagline {
  font-family: "Source Serif 4", Georgia, serif;
  font-style: italic;
  font-size: 1.2rem;
  color: var(--teal-bright);
  margin: 0 0 18px;
}
.ph-site-hero .ps-sub {
  font-size: 1.05rem;
  color: var(--on-navy-muted);
  max-width: 54ch;
  margin: 0 0 24px;
}
.ph-hero-ctas { display: flex; flex-wrap: wrap; gap: 10px; margin-bottom: 20px; }
.ph-hero-cta {
  display: inline-flex;
  align-items: center;
  gap: 8px;
  font-family: "IBM Plex Mono", monospace;
  font-size: 0.82rem;
  font-weight: 500;
  padding: 11px 18px;
  border-radius: 7px;
  text-decoration: none;
  transition: transform 0.15s ease, background 0.15s ease;
}
.ph-hero-cta.primary { background: var(--teal-bright); color: var(--navy-deep); }
.ph-hero-cta.primary:hover { transform: translateY(-1px); }
.ph-hero-cta.secondary { background: transparent; border: 1px solid var(--navy-line); color: var(--on-navy); }
.ph-hero-cta.secondary:hover { border-color: var(--teal-bright); color: var(--teal-bright); }

.ph-hero-visual { position: relative; z-index: 2; aspect-ratio: 1 / 1; max-width: 420px; margin: 0 auto; }
.ph-hero-visual svg { width: 100%; height: 100%; }

@media (prefers-reduced-motion: no-preference) {
  .ph-hero-visual .motif-draw {
    stroke-dasharray: 600;
    stroke-dashoffset: 600;
    animation: ph-draw 2.4s ease forwards;
  }
  @keyframes ph-draw { to { stroke-dashoffset: 0; } }
}

/* ---------- explore-the-evidence routing cards ---------- */
.ph-explore-grid {
  display: grid;
  grid-template-columns: 1fr;
  gap: 16px;
}
@media (min-width: 780px) {
  .ph-explore-grid { grid-template-columns: repeat(3, 1fr); }
}
.ph-explore-card {
  display: flex;
  flex-direction: column;
  gap: 10px;
  background: var(--paper-raised);
  border: 1px solid var(--line);
  border-top: 3px solid var(--accent);
  border-radius: 10px;
  padding: 22px 22px 20px;
  text-decoration: none;
  color: var(--ink);
  transition: transform 0.15s ease, box-shadow 0.15s ease;
}
.ph-explore-card:hover { transform: translateY(-2px); box-shadow: 0 14px 28px rgba(14,27,36,0.08); }
.ph-explore-card .ph-icon { width: 24px; height: 24px; color: var(--accent); }
.ph-explore-card h3 { font-family: "Source Serif 4", Georgia, serif; font-size: 1.15rem; margin: 4px 0 2px; }
.ph-explore-card p { margin: 0; font-size: 0.9rem; color: var(--muted); }
.ph-explore-card .ph-explore-cta { margin-top: 6px; font-family: "IBM Plex Mono", monospace; font-size: 0.78rem; color: var(--accent); }

/* ---------- featured research grid ---------- */
.ph-featured-grid {
  display: grid;
  grid-template-columns: 1fr;
  gap: 16px;
}
@media (min-width: 780px) {
  .ph-featured-grid { grid-template-columns: repeat(2, 1fr); }
}
.ph-featured-card {
  display: block;
  background: var(--paper-raised);
  border: 1px solid var(--line);
  border-radius: 10px;
  overflow: hidden;
  text-decoration: none;
  color: var(--ink);
  transition: border-color 0.15s ease;
}
.ph-featured-card:hover { border-color: var(--accent); }
.ph-featured-card .ph-featured-band {
  height: 72px;
  position: relative;
  overflow: hidden;
}
.ph-featured-card .ph-featured-band svg { width: 100%; height: 100%; }
.ph-featured-card .ph-featured-body { padding: 16px 18px 18px; }
.ph-featured-card .ph-featured-kicker { font-family: "IBM Plex Mono", monospace; font-size: 0.68rem; text-transform: uppercase; letter-spacing: 0.05em; color: var(--accent); margin-bottom: 6px; }
.ph-featured-card h3 { font-family: "Source Serif 4", Georgia, serif; font-size: 1.1rem; margin: 0 0 6px; }
.ph-featured-card p { margin: 0; font-size: 0.88rem; color: var(--muted); }

/* ---------- motion: card lift, generic ---------- */
.ps-card, .el-profile-card, .ct-trial-card, .ps-continue-item, .ps-explainer, .reg-compound-card {
  transition: transform 0.15s ease, border-color 0.15s ease, box-shadow 0.15s ease;
}
.el-profile-card:hover, .ct-trial-card.clickable:hover, .ps-continue-item:hover {
  transform: translateY(-2px);
  box-shadow: 0 10px 22px rgba(14,27,36,0.07);
}

/* ---------- dark footer bookend ---------- */
.ps-footer.ph-navy {
  padding-block: 44px 28px;
}
.ps-footer.ph-navy .ps-footer-grid {
  border-bottom-color: var(--navy-line);
}
.ps-footer.ph-navy .ps-footer-col-title { color: var(--teal-bright); }
.ps-footer.ph-navy .ps-footer-col a { color: var(--on-navy-muted); }
.ps-footer.ph-navy .ps-footer-col a:hover { color: var(--on-navy); }
.ps-footer.ph-navy .ps-footer-bottom p { color: var(--on-navy-muted); }
.ps-footer.ph-navy .ps-footer-bottom a { color: var(--teal-bright); }

@media (prefers-reduced-motion: reduce) {
  .ps-nav { backdrop-filter: none; }
  .ps-nav-caret { transition: none; }
  .ph-hero-cta, .ph-explore-card, .el-profile-card, .ct-trial-card, .ps-continue-item, .ps-card {
    transition: none;
  }
  .ph-hero-visual .motif-draw { animation: none; stroke-dashoffset: 0; }
}